Semmelweis Kiadó ; S1: ORVOSKÉPZÉS - PDF Free Download

Papilloma az inguinalis motívumfórumon.

Karasev, M. Over a long period of time only necrosis was considered to be a mechanism of myocardial cell death occurring due to various pathological states. In the recent years much more attention has been paid to apoptosis of cardiomyocytes for it may also be one of pathogenetic factors contributing to the development of heart failure, as it was hypothesized by a number of authors.

In particular, it was shown that apoptosis rate significantly increased in the myocardium under chronic hemodinamic overload. Papilloma az inguinalis motívumfórumon there is still very little data concerning the effect of acute cardiac overload on programmed cardiomyocyte death and myocardial structure. The experiment was performed on 20 male Chinchilla rabbits weighing Acute overload of the left ventricle LV was induced in narcotized animals by aortic narrowing with the use of metal spiral.

The control group comprised intact rabbits.

Prosztatagyulladás kezelése népi c 7

Morphological study of the LV was carried out by light microscopy of semi-thin sections. Cardiomyocyte apoptosis was investigated by morphological and immunihistohemical TUNEL-assay methods.

It was found that the left ventricular myocardium underwent profound morphological changes mainly characterized by severe tissue damage: on day 1 the area of destruction sites was 13,4 times as much as in the controls and then remained at nearly the same level.

There was also a considerable expansion of extracellular space which is evidence of tissue oedema.

papilloma az inguinalis motívumfórumon

According to morphological data, there was a progressive increase in apoptotic index in the left ventricular myocardium as the pathological process developed. Immunohistochemical tests revealed a significant rise of TUNEL-positive cardiomyocytes at all investigated terms with peak value on day 3.

Thus, in acute cardiac overload caused by aortal stenosis the number of viable cardiomyocytes of the LV may be reduced both due to cell injury and also owing to apoptotic death involvement. Supervisor s : Blagonravov M. A common denominator underlying maladies of the geriatric population, is aging itself.

It is likely that both environmental and genetic factors dictate the rate of aging process; much has been done in identifying those belonging in the former tier, but little is known about those that comprise the latter.

Semmelweis Kiadó ; S1: ORVOSKÉPZÉS - PDF Free Download

Mitochondrial dysfunction has been implicated in aging. Mitochondrial functions rely exclusively on compartmentalization, demanding an intact inner membrane for the development of membrane potential.

papilloma az inguinalis motívumfórumon

However, upon stressful stimuli, mitochondria form a pore across the two membranes, by recruiting intrinsic proteins. The expression of all other aging markers exhibited no statistically significant difference.

Our results are combined with those obtained by different approaches, in which the very same mice have been evaluated for behavioral alterations, while végbélrák csípőfájdalom brains of other mice are being evaluated for region-specific alterations in the expression of aging markers by immunocytochemistry. The results obtained from the overall work may provide valuable information in terms of pinpointing cyclophilin D as a target for an aging-combating drug.

Relevant to this, cyclophilin D-inhibiting drugs are available, and have been approved for human use, currently papilloma az inguinalis motívumfórumon clinical trials for unrelated maladies.

Chinopoulos C, Adam-Vizi V. FEBS J. J Biol Chem. Effect of knocking out cyclophilin D on region-specific distribution of mGlur1 and GFAP expression in the mouse brain Lilla Kepes, Semmelweis University Faculty of Medicine 4th year Effects of whole body cryotherapy on chosen parameters of cardiovascular system Lukac Stefan, Comenius University Faculty of Medicine 2nd year [email protected] Genetic proof that the mitochondrial protein cyclophilin D cypD plays a major role in the manifestation of necrotic cell death was established by using genetically engineered cypD knock out mice.

However, mGluR1 expression exhibited a significantly different pattern of expression in brain regions among the three groups, a finding that could not have been yielded from western blotting alone. These results will be cross-correlated by those obtained by evaluating behavioral alterations from the same mice prior to the processing of their brains.

papilloma az inguinalis motívumfórumon

These efforts may provide valuable information in terms of pinpointing cyclophilin D as a target for an aging-combating drug. Supervisor s : Christos Chinopoulos, Adjunct Professor, Department of Medical Biochemistry, Semmelweis University Whole body cryotherapy WBCT is a supporting therapeutic method that uses application of extremely low temperatures — °C— °C and its surface stimulating effects on the human body.

papilloma az inguinalis motívumfórumon

It is used mainly for treatment of musculoskeletal injuries, skin diseases or multiple sclerosis. Our work was focused on cryotherapy-caused effects in hemodynamic parameters as a risk factor for patients undergoing treatment by cold. We studied gender and age differences. No proband suffered from any cardiovascular disease, nor used any medication affecting BP and PF. Significant increase in systolic BP was found in both groups p 0.

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RI represents myocardial oxygen consumption and load on cardiovascular system. A statistical significance was observable only in females older than 40 years.

Prosztatagyulladás kezelése népi c 7

We can conclude that WBCT causes an increase in both systolic and diastolic BP, decrease PF regardless of both gender and age and does not cause any significant change in oxygen consumption by myocardium.

Thus we could recommend WBCT as the safe method for the regeneration of healthy subjects without persisted cardiovascular disease.

papilloma az inguinalis motívumfórumon

Lukáè Š. Haemodynamic response of cardiovascular system on whole—body cryotherapy. Book of abstracts: Interactive conference of young scientists. Banská Bystrica : Civic Association Preveda,p. ISBN —80——0—2. Lukáè Š, Krá¾ová E. The study of cardiovascular system response after exposure to whole—body cryotherapy. In: Ladziansky´s message for future generations II.

Semmelweis Kiadó 2012; S1: ORVOSKÉPZÉS

Kubíková, E. Bratislava: Únia,p. ISBN —80——3—7.

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Eva Kralova, PhD. Expression of a-SMA in hepatic stellate cells as their activation biomarker papilloma az inguinalis motívumfórumon down-regulated immune response in human hydatid infection Ali Vatankhah, Semmelweis University Faculty of Medicine — József Tímár, Semmelweis University 2nd Department of Pathology [email protected] ; [email protected] Fibrosis is one of the most important pathological manifestations of chronic hydatid infection CHI.

Inflammatory response induces proliferation and migration of macrophages that in turn generate stimulatory signals for hepatic stellate cells HSCs activation. This process has an essential role in tissue fibrosis during chronic liver injuries and can be characterized by expression of cytoplasmic smooth muscle actin-alpha a-SMA.

In vitro studies along with animal experiments have indicated that hydatid cyst antigens may induce down-regulated Th1-like immunity as well as suppressed macrophage activation; however it is still unclear whether how the fibrotic tissue can be formed around the hydatid lesion in the course of chronic infection.

papilloma az inguinalis motívumfórumon